| Train | Source | Destination | Days Run from Rameswaram |
| 22621 - Rmm Cape Sf Express | Rameswaram (RMM) | Kanniyakumari (CAPE) | Tue Sun |
| # | Station | Arrival | Departure | Halt | Distance | Day |
| 1 | Rameswaram (RMM) | Source | 08:50 PM | 0 Mins | 0 KMs | 1 |
| 2 | Ramanathapuram (RMD) | 09:38 PM | 09:40 PM | 2 Mins | 54 KMs | 1 |
| 3 | Paramakkudi (PMK) | 10:03 PM | 10:05 PM | 2 Mins | 90 KMs | 1 |
| 4 | Manamadurai Jn (MNM) | 10:28 PM | 10:30 PM | 2 Mins | 114 KMs | 1 |
| 5 | Madurai Jn (MDU) | 11:45 PM | 11:50 PM | 5 Mins | 161 KMs | 1 |
| 6 | Virudunagar Jn (VPT) | 12:23 AM | 12:25 AM | 2 Mins | 204 KMs | 2 |
| 7 | Tirunelveli Jn (TEN) | 02:12 AM | 02:15 AM | 3 Mins | 318 KMs | 2 |
| 8 | Valliyur (VLY) | 02:44 AM | 02:45 AM | 1 Mins | 360 KMs | 2 |
| 9 | Nagercoil Junction (NCJ) | 03:20 AM | 03:23 AM | 3 Mins | 391 KMs | 2 |
| 10 | Kanniyakumari (CAPE) | 04:05 AM | Destination | 0 Mins | 406 KMs | 2 |